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The duration of anticoagulation after a child's first deep venous thrombosis (DVT) often is determined based on genetic predisposition to thrombosis. The lack of prospective data to inform prescribing decisions led researchers to develop a decision analysis model to estimate the costs and effects (in quality-adjusted life-years [QALYs]) of three clinical strategies: no thrombophilia testing and anticoagulation for 3 months; no thrombophilia testing and anticoagulation for 6 months; and thrombophilia testing followed by 3 or 6 months of anticoagulation, depending on test results. Estimates of DVT recurrence risk (with and without thrombophilia); anticoagulation-associated morbidity and mortality; and costs of hospitalization, testing, medica…