Risk for Cardiovascular Disease in Adult Survivors of Childhood Cancer

Childhood cancer is associated with lifelong excess risk for cardiac disease.

Cardiac events are the leading cause of mortality in childhood cancer survivors. To examine risk for morbidity associated with cardiovascular disease, investigators surveyed 14,359 5-year cancer survivors (54% males) in whom cancer was diagnosed before age 21 years (median age, 6 years) and 3899 of their siblings. More than half the survivors received both anthracyclines and radiation, 11% received radiation and surgery, 18% received chemotherapy and surgery, and <1% received radiation alone.

The adjusted risk for an adverse cardiac event was five to six times higher for survivors than for siblings; risk for pericardial disease was highest (hazard ratio, 6.3), followed by congestive heart failure (CHF; HR, 5.9), myocardial infarction (HR, 5.…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)