Family History Is Important to Consider in the Diagnosis of Pyloric Stenosis

Heredity accounts for most of the risk.

Pyloric stenosis is the most common reason for surgery in infants and is known to aggregate in families. Researchers examined the degree to which heredity accounts for pyloric stenosis in a population-based cohort study of nearly 2 million children born in Denmark between 1977 and 2008. Familial aggregation was evaluated by rate ratios according to family history (incidence in infants with and without relatives with pyloric stenosis) and type of relative.

During the study period, 3362 children underwent surgery for pyloric stenosis (81% boys). The overall incidence of pyloric stenosis was 2.7 per 1000 person-years in boys and 0.7 per 1000 person-years in girls, and the rate in twins was 3.1. Rate ratios of pyloric stenosis by twin status wer…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)