Coadministration of Adolescent Vaccines: Give Them When You Can

Achieving optimal vaccination levels in adolescents will likely be enhanced if several vaccines can be administered simultaneously. In a multicenter, open-label, randomized study funded by the manufacturer of the human papillomavirus (HPV) vaccine Gardasil, researchers examined the safety and immunogenicity of concomitant administration of Gardasil with meningococcal (Menactra), and Tdap (tetanus, diphtheria, pertussis; Adacel) vaccines in 394 boys and 648 girls aged 10–17 years. The adolescents were randomized to one of two vaccine schedules: concomitant administration (the first Gardasil dose in 1 arm and Menactra and Adacel vaccines in the other arm on day 1, followed by the other Gardasil doses at 2 and 6 months) or nonconcomitant admin…