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Childhood obesity and parental body-mass index (BMI) predict adult obesity, but whether risk factors such as markers of inflammation or genetic polymorphisms improve predictive models is unknown. To examine childhood environmental and genetic risk factors for adult obesity, investigators in Finland followed 2119 participants (age range at enrollment, 3–18 years; mean age, 11 years) for 27 years in a population-based longitudinal study.
The following childhood factors were directly and significantly associated with adult obesity: childhood BMI, maternal and paternal BMIs, birth weight, insulin level, systolic blood pressure, C-reactive protein (CRP) level, aggression-prone negative emotionality, and polymorphisms near three obesity-related ge…