Nocturnal Temperature-Controlled Laminar Airflow Therapy for Asthma

Asthma quality-of-life scores were improved in patients with poorly controlled asthma.

Efforts to demonstrate that a reduction in allergen exposure improves asthma control have been disappointing. In an industry-sponsored, multicenter, double-blind, placebo-controlled trial, researchers examined the effects of nocturnal temperature-controlled laminar airflow (TLA) therapy for 12 months in 282 patients (age range, 7–70 years) with atopic asthma. Active TLA devices were installed in overhead positions in bedrooms of 189 patients, and placebo devices were installed in bedrooms of 93 patients. Devices were turned on at bedtime and off in the morning.

After 1 year, the absolute treatment response rate based on changes in asthma quality-of-life questionnaire (AQLQ) scores from baseline was significantly higher in the TLA group than …

Reviewing Author

F. Bruder Stapleton, MD

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Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Nocturnal Temperature-Controlled Laminar Airflow Therapy for Asthma

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Reviewing Author