A Noninvasive Test for Severe Vesicoureteral Reflux

Urinary proteome analysis showed promise in excluding high-grade VUR.

To diagnose vesicoureteral reflux (VUR) currently requires a voiding cystourethrogram (VCUG), which exposes a child to radiation and discomfort. At four hospitals in Europe, researchers examined how well capillary-electrophoresis mass spectroscopy of urinary proteins identifies biomarkers of high-grade VUR. VCUG was used as the gold standard. The study was led by the founder and co-owner of the company that developed the urinary proteome analysis system.

Of 73 children with suspected VUR who met inclusion criteria, 18 with severe (grade IV–V) VUR and 19 without VUR (controls) were randomly selected for identification of urinary proteome patterns. Comparative urinary proteome analysis revealed nine polypeptides associated with severe VUR; all…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)