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Kawasaki disease (KD) is an acute systemic vasculitis in children that might result in coronary artery aneurysms. In a multicenter randomized trial, researchers examined the efficacy of adding prednisolone to standard treatment with intravenous (IV) immunoglobulin and aspirin in 248 children in Japan with severe KD: 123 patients received standard treatment, and 125 children received standard treatment plus IV prednisolone (2 mg/kg/day) for at least 5 days followed by tapered doses of oral prednisolone. A risk score was used to identify patients at high risk for a lack of response to initial treatment with IV immunoglobulin based on serum sodium concentrations <133 mmol/L, ≤4 days of illness at diagnosis, aspartate aminotransferase concentra…