Pediatric-Specific Antibiotic Susceptibilities Differ from Adult Antibiograms

Knowledge of pediatric-specific antibiotic susceptibilities could improve our ability to choose appropriate empiric antibiotics for childhood infections.

Researchers at Duke University Health System hypothesized that annual antibiograms generated from combined data for both adult and pediatric isolates might hide significant susceptibility differences between adults and children. To test this hypothesis, they abstracted 375 Escherichia coli isolates from electronic medical records (from July 2009 through September 2010) for patients aged ≤12 years and compared rates of resistance between hospital-wide and pediatric-specific data. Compared with the combined antibiogram, pediatric isolates were significantly more likely to be resistant to amoxicillin, amikacin, and trimethoprim-sulfamethoxazole and less likely to be resistant to amoxicillin-clavulanate and ciprofloxacin.

To examine the effect o…

Reviewing Author

Louis M. Bell, MD

Disclosures

Grant/Research SupportNIH Institutional Clinical and Translational Science Award; Agency for Healthcare Research and Quality National Center for Pediatric Practice Based Research Learning; Patient-Centered Outcomes Research Institute

Editorial BoardsCurrent Problems in Pediatric Adolescent Healthcare

Leadership Positions in Professional Societies College of Physicians of Philadelphia (Board of Trustees)

Louis M. Bell, MD

Disclosures

Editorial BoardsCurrent Problems in Pediatric Adolescent Healthcare

Leadership Positions in Professional Societies College of Physicians of Philadelphia (Board of Trustees)

Pediatric-Specific Antibiotic Susceptibilities Differ from Adult Antibiograms

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Reviewing Author