Puberty Triggers Progression of Renal Failure in Children with Chronic Kidney Disease

Glomerular filtration rate fell rapidly after age 10.9 years in girls and 11.6 years in boys.

Pediatric nephrologists have recognized that children with chronic kidney disease (CKD) progress rapidly to end-stage renal failure, requiring renal replacement therapies (RRT) during adolescence. The mechanism of the deterioration is poorly understood, and rigorous documentation of this phenomenon has not occurred. Researchers used data from the Italian National Registry of Renal Failure to examine the rate of decline in calculated glomerular filtration rate (cGFR) in 935 children (age, <20 years; mean, 6 years) with chronic renal insufficiency (cGFR <90 mL/min/1.73 m²; mean, 42.7 ml/min/1.73m²).

Between 1990 and 2002, the registry had 703 children with both hypodysplasia and urologic abnormality and 232 with isolated hypodysplasia. Using R…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)