Nonsteroidal Anti-Inflammatory Drug-Associated Kidney Injury in Children

NSAIDS were associated with acute kidney injury even at recommended doses.

Many drugs, including nonsteroidal anti-inflammatory drugs (NSAIDs), can lead to serious kidney injury. To describe NSAID-associated acute kidney injury (AKI) in children, researchers in Indiana retrospectively reviewed medical charts of 1015 children (age, <18 years) who were admitted to a children's hospital with AKI (elevated serum creatinine and elevated glomerular filtration rate [eGFR] <75 mL/min/1.73 m²) in January 1999 through June 2010. NSAID-associated AKI excluded children with comorbid conditions, multifactorial AKI, or alternate cause of AKI.

In all, 27 children (2.7%) had NSAID-associated AKI; 67% had used ibuprofen, 78% had used NSAIDs for <7 days, and 75% had received recommended dosing. The most common presenting symptoms we…

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)