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Nonoxynol 9 is an effective spermicide and has been recommended for use as a microbicide as well because it inactivates STD pathogens in laboratory studies. However, studies of its efficacy in prevention of STD transmission have had conflicting results. This clinical trial in Cameroon examined the effect of a nonoxynol 9 film (70 mg), inserted vaginally before intercourse, on the rate of STD transmission in 1,292 HIV-negative prostitutes. Researchers randomized the women to nonoxynol 9 or a placebo film and distributed latex condoms and instructions for their use along with the film.
All the women had baseline pelvic examinations using colposcopy. Monthly follow-up examinations included colposcopy for lesions, endocervical specimens and DNA …