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To compare the prevalence of major birth defects between infants conceived naturally and those conceived through assisted reproductive technology (ART), these authors gathered data from a reproductive technology registry, a birth registry, and a birth-defects registry in Western Australia between 1993 and 1997. Four thousand infants were naturally conceived, 837 were conceived through in vitro fertilization (IVF), and 301 were conceived through IVF with intracytoplasmic sperm injection (ICSI).
Major birth defects were diagnosed by age 1 year in 26 (8.6%) ICSI infants, 75 (9.0%) IVF infants, and 168 (4.2%) naturally conceived infants. Although the risk for birth defects did not differ significantly between ICSI and IVF infants, it was 2-fold …