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Benign endometrial cells on a Pap smear can be a normal finding in reproductive-aged women (Journal Watch Women's Health Jan 9 2001), but the significance of this finding in postmenopausal women is controversial. In a review of 52,662 Pap smears from postmenopausal women, these investigators sought to determine the prevalence of such a finding and to compare prevalence and histologic diagnosis in women who use hormone therapy (HT) and those who do not.
A total of 589 (1.1%) Pap smears with benign endometrial cells were identified. Of these, 245 were from HT users, 324 were from nonusers, and 20 were from women whose hormonal status was unknown. Prevalence of benign endometrial cells was significantly higher in HT users than in nonusers (rela…