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Data regarding an association between caffeine intake and spontaneous abortion have been inconsistent. Precluding a crisp answer to this dilemma are various confounders, such as recall bias in case-control studies. These researchers examined the association between spontaneous abortion and pre-pregnancy caffeine intake in a nested, case-control, prospective study of 11,088 Danish women (age range, 20-29) who were identified from 1991 to 1993 for a study examining the natural history of human papillomavirus and cervical neoplasia.
During interviews at initial enrollment, the women provided sociodemographic information and completed food-frequency questionnaires. Caffeine intake was estimated: 1 cup of tea was considered to contain 34 mg of ca…