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Vaginal birth after previous low transverse cesarean section appears to be safe in women undergoing a trial of labor after spontaneous onset. However, many trial-of-labor patients require labor induction, and controversy remains about the effects of induction with prostaglandins on risk for uterine rupture. In the current study among women with singleton pregnancies and previous low transverse C-section, Italian researchers examined whether risk for uterine rupture was higher in women undergoing labor induction (n=310) than in those with spontaneous labor onset (n=1011).
For labor induction, prostaglandin E2 was applied intracervically every 8 hours or intravaginally every 12 hours until the Bishop score was >6 or four doses had been adminis…