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Women in the U.S. are delaying childbirth. These investigators evaluated the risks of delayed pregnancy to mother and baby in an unselected obstetric population. They examined data from the First and Second Trimester Evaluation of Risk (FASTER) trial -- an NIH-sponsored study designed to determine the efficacy of first- and second-trimester screening for Down syndrome in singleton pregnancies. As part of the FASTER trial, maternal and infant complications were recorded.
Of 36,056 women, 79% were younger than 35 (reference group), 17% were 35 to 39, and 4% were 40 or older. Analyses were adjusted for numerous confounders, including race, parity, BMI, smoking status, preexisting medical conditions, previous adverse pregnancy outcomes, and use …