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Topical and systemic estrogen increases skin thickness, collagen content, blood flow, and water content in postmenopausal women. Accordingly, in a previous study, women using hormone therapy were less likely than nonusers to experience pressure ulcers and venous leg ulcers (Lancet 2002; 359:675). In the current observational study, investigators evaluated the cosmetic effects of long-term HT use on the skin. They evaluated skin wrinkling and rigidity among 11 women who had never used postmenopausal HT and 9 women who had been using HT consistently since within 1 year of their last menstrual period; all participants were at least 5 years postmenopausal. Women with histories of plastic surgery, known collagen disorders, and skin disease were …