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Two recent reports from the Women’s Health Study provide insight into the effects of aspirin on cancer risk and the effects of vitamin E on heart disease and cancer risk in women.
NIH-supported researchers randomized 39,876 female healthcare professionals (age, ≥45) without known cancer or cardiovascular disease to receive aspirin (100 mg every other day) plus placebo; vitamin E (600 IU every other day) plus placebo; both active treatments; or double placebo. Participants annually reported clinical endpoints on written questionnaires, and researchers followed any positive report with a blinded review of the participant’s medical records. Primary analyses were performed according to the intent-to-treat principle.
During an average follow-up of…