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Invasive prenatal procedures remain necessary for the definitive diagnosis of fetal chromosomal abnormalities. Noninvasive methods such as triple analyte screening ultimately require a confirmatory invasive procedure before decisions regarding the pregnancy can be exercised. Amniocentesis remains the most common prenatal karyotyping procedure in the U.S., despite the disadvantage that it cannot be performed prior to 14 weeks’ gestation. Chorionic villus sampling (CVS), although a first-trimester procedure, is less frequently performed. In this retrospective study, the investigators tabulated rates of spontaneous pregnancy loss in patients who underwent CVS or amniocentesis compared with patients who did not undergo these procedures during a…