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The development of several markers and strategies for prenatal detection of Down syndrome has prompted the American College of Obstetricians and Gynecologists to update its practice guidelines for screening for fetal chromosomal abnormalities. Counseling all pregnant women, regardless of age, about the availability of screening tests for fetal aneuploidy is now recommended. Several screening schema have been evaluated; many include the combination of biochemical markers (e.g., serum pregnancy-associated plasma protein [PAPP-A] and free or total β-human chorionic gonadotropin [β-hCG]) and ultrasound-guided measures of nuchal translucency. In light of these options, the detection rate for Down syndrome varies from 70% to 95%, with a 5% false-…