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Nulliparity and infertility are risk factors for ovarian cancer. Previous epidemiologic and cohort studies have suggested that treatment with fertility drugs might impart risk for ovarian cancer in nulliparous women. To evaluate risk associated with fertility drugs, researchers evaluated data from 54,362 Danish women (156 ovarian cancer cases, 1380 controls without ovarian cancer) who attended fertility clinics from 1963 through 1998.
Median follow-up was 16 years, and median age at ovarian cancer diagnosis was 46 (range, 25–68). Approximately one third of cases and controls used clomiphene, and another one third used human chorionic gonadotrophins; gonadotrophins and gonadotrophin-releasing hormone were used by about 15% and 10% of particip…