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Publication of the Women’s Health Initiative (WHI) data in July 2002 led to a drop-off in use of estrogen-containing hormone therapy — one of the most effective modalities to prevent osteoporotic fractures. Has this decline in HT use caused higher fracture rates? In an industry-sponsored study, investigators used a database of claims from multiple health plans to examine changes in fracture incidence among 40- to 69-year-old women from January 1, 2000, to December 31, 2005.
Annual health-plan enrollment of eligible women increased from 900,000 in 2000 to 2.9 million in 2005, during which time more than 43,000 fractures in this group were reported. HT use fell from 101 per 1000 women in 2000 to 33 per 1000 women in 2005, and use of nonhormona…