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Because hormone therapy is associated with higher breast density, some clinicians have recommended that users temporarily suspend HT before undergoing screening mammography. In a federally funded trial, investigators recruited women who were using HT at the time of their most recent (i.e., index) screening mammograms and were still using HT when their next screens were due. Almost two thirds of 4884 eligible women declined to participate, primarily because they were unwilling to suspend HT use. Others were randomized to no suspension or to 1- or 2-month suspension of HT before screening mammography. Of 1471 participants (mean age, 60), 92% were white.
Recall rates were similar in the no-suspension (11%), 1-month suspension (12%), and 2-month…