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Several medical approaches are available for management of abnormal uterine bleeding during the reproductive years. Italian investigators assessed the efficacy of vaginally administered danazol (a synthetic steroid that suppresses the pituitary–ovarian axis) for treating women with heavy menstrual bleeding. Fifty-five women (median age, 33) with histories of heavy menstrual bleeding underwent biopsies to exclude endometrial hyperplasia, polyps, and submucous fibromas. Participants inserted single 200-mg vaginal danazol tablets nightly for 6 months and recorded menstrual bleeding (on a visual analog scale), side effects, and pain.
At 6 months, all women reported shorter menses (from 6 to 3 days) and fewer pads or tampons used (from 6 to 2 dai…