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As the number of young cancer survivors grows, so do concerns about the effects of treatment on reproductive outcomes. In a retrospective cohort study based on Surveillance, Epidemiology and End Results cancer registries and on birth records, researchers evaluated outcomes of first live births in almost 2000 women with histories of childhood or adolescent cancers (genital tract cancers were analyzed separately) compared with 14,300 women without cancer histories.
Overall, cancer survivors' offspring were not at excess risk for malformations or infant death; moreover, sex ratios were similar to those in children of women who did not have childhood or adolescent cancer histories. Infants born to cancer survivors were more likely to be delivere…