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To determine whether women with preeclampsia are at excess risk for hypothyroidism, researchers compared thyroid-stimulating hormone (TSH) levels before 21 weeks' gestation and after the onset of preeclampsia, but before delivery, in 141 women with preeclampsia and 141 normotensive pregnant controls.
Significantly more women with preeclampsia had predelivery TSH levels above the reference range (indicating potential for clinically significant thyroid malfunction) than did controls (24% vs. 14%). After adjusting for age, BMI, race or ethnicity, smoking status, human chorionic gonadotrophin concentration, and presence of thyroid peroxidase antibodies, preeclampsia was associated significantly with higher risk for TSH levels above the reference…