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Since the publication of the Women's Health Initiative results (JW Womens Health May 2 2006), hormone therapy (HT) has been recommended only for women who have substantial symptoms at menopause — and then only for as long as necessary to alleviate symptoms. But is HT best discontinued abruptly or by tapering? To address this question, Swedish investigators conducted a multicenter trial of 81 women (median age, 59) who had used HT for 3 to 11 years. More than one third of participants used 1-mg estradiol plus 0.5-mg norethindrone acetate daily, 25% used estradiol plus medroxyprogesterone acetate, and 10% used tibolone or higher daily doses of estradiol.
Women were randomized to stop HT abruptly or to take their usual doses every other day for…