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Hypertensive disorders during pregnancy (chronic hypertension, gestational hypertension, preeclampsia, or eclampsia) complicate about 7% of pregnancies among U.S. women. Obesity is associated with excess risk for preeclampsia and might also raise risk for other hypertensive pregnancy disorders. Investigators conducted a retrospective analysis of claims data from 2002 through 2006 that involved 585 women who underwent bariatric surgery (82% gastric bypass) before or after a pregnancy; 269 delivered before surgery, and 316 delivered afterward.
Almost 15% of women who underwent bariatric surgery after pregnancy developed preeclampsia or eclampsia, whereas these disorders occurred in only 3% of women who underwent such surgery before pregnancy. Similarly, gestational hypertension (13% vs. 2%; P<0.001), chronic hypertension (14% vs. 5%; P<0.001), and preeclampsia or eclampsia superimposed on chronic hypertension (12% vs. 1%; P<0.001) occurred significantly less often in postbariatric pregnancies. Overall, bariatric surgery lowered risk for any hypertensive disorder during pregnancy by 75%.
Bennett WL et al. Impact of bariatric surgery on hypertensive disorders in pregnancy: Retrospective analysis of insurance claims data. BMJ 2010 Apr 13; 340:c1662. (http://dx.doi.org/10.1136/bmj.c1662)
Comment
Although this study has several important limitations (insurance data lacked information about height, weight, and parity and could have been subject to selection bias), the results support use of bariatric surgery in obese women to help lower risk for hypertensive complications during subsequent pregnancies. As part of preconception evaluation, bariatric surgery should be considered for women with body-mass index >40 (or >35 with comorbidities). Bariatric surgery, especially Roux-en-Y procedures, predisposes women to malabsorption with attendant nutrient and vitamin deficiencies. For care of pregnant women who have undergone bariatric surgery, clinicians should consult a recent bulletin published by the American College of Obstetricians and Gynecologists (Obstet Gynecol 2009; 113:1405).