Pelvic Irradiation for Childhood Cancer Raises Risk for Stillbirth Among Subsequent Offspring

Pelvic irradiation in girls (but not testicular irradiation in boys) was associated with excess risk for stillbirth or neonatal death among their offspring.

As the number of adult survivors of childhood cancers rises, interest in their reproductive potential has grown. Investigators used data from the multicenter Childhood Cancer Survivor Study (CCSS) in a retrospective cohort analysis of risk for stillbirth and neonatal death among offspring of 2805 survivors of childhood cancers (1148 men and 1657 women).

In all, 4853 live births and 93 stillbirths and neonatal deaths occurred; among the 1774 survivors who received pelvic radiotherapy, 3077 live births and 60 stillbirths and neonatal deaths occurred. Mothers who received radiation that involved the ovaries and uterus before menarche showed a dose-related excess risk for stillbirth (for doses ≥2.5 Gy, adjusted relative risk, 12.3, 95% confidenc…

Reviewing Author

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Robert W. Rebar, MD

Disclosures

Consultant/Advisory BoardMyovant Sciences, Inc.

Editorial BoardsEndoText; Clinical OB/GYN Alert

Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)

Pelvic Irradiation for Childhood Cancer Raises Risk for Stillbirth Among Subsequent Offspring

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Reviewing Author