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Previous studies have suggested that women with polycystic ovary syndrome (PCOS) are at excess risk for abnormal depression scores on screening. But is the pattern sufficiently clear to warrant screening of all women with PCOS? Investigators conducted a systematic review and meta-analysis that included 10 cross-sectional studies that involved 522 women with well-documented PCOS and 475 women without PCOS who were screened for depression. The psychological instruments varied among studies, but the Beck Depression Inventory was used most commonly.
Women with PCOS were fourfold more likely to have abnormal depression scores than were women without PCOS (odds ratio, 4.03; 95% confidence interval, 2.96–5.50). Subanalysis indicated that odds of ha…