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Data conflict on adverse obstetric outcomes in women with epilepsy, raising the question of whether these effects result from the disease itself, from antiepileptic drugs, or from clinicians' decisions about management. In a retrospective study in Norway, researchers evaluated delivery outcomes in 205 women with epilepsy (active: seizures <5 years before conception; nonactive: seizures ≥5 years before conception) and 205 age- and parity-matched women without epilepsy.
Overall, 57% of women with epilepsy used antiepileptic drugs during pregnancy; of these, 72% had active epilepsy. Compared with women who did not have epilepsy, those with epilepsy who used antiepileptic drugs had excess risk for severe preeclampsia, bleeding during early pregn…