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Most studies of soy have not demonstrated clinically important efficacy in menopausal women; nonetheless, women remain interested in whether soy-derived supplements alleviate menopausal symptoms. Investigators in south Florida randomized nonosteoporotic women with onset of menopause ≤5 years before enrollment to receive daily soy isoflavones (200 mg) or placebo for 2 years. Outcomes assessed at baseline and at 12 and 24 months included spine and hip bone-mineral density (BMD), menopausal symptoms, and vaginal epithelial maturation. In all, 248 women (mean age, 52; two thirds white Latina, one quarter white non-Latina, and 10% black) were enrolled.
At baseline, more than two thirds of participants reported ≥1 menopausal symptom; vaginal matur…