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Therapeutic advances have prolonged survival among both younger and older women with breast cancer. However, concerns about early menopause, infertility, and emotional health are more likely in younger survivors. Investigators performed a systematic review of studies concerning quality of life (QOL), menopausal or fertility-related symptoms, and behavioral outcomes in younger breast cancer survivors (age ≤50 years or premenopausal at diagnosis).
Depressive symptoms were more common and more severe in younger survivors than in older survivors or in age-matched women without cancer. QOL scores were lower in younger survivors than the national reference score for similar-age women without cancer. Women with chemotherapy-induced menopause had mo…