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Legally performed suction or medical induced abortion is safe for women (JW Womens Health Jun 4 2009). Given the large number of women who terminate pregnancies each year (JW Womens Health Feb 23 2012), interventions that increase the safety of induced abortion even further have great global health relevance. To evaluate the effects of administering vaginal misoprostol 3 hours before first-trimester suction abortion, researchers for the WHO conducted a randomized placebo-controlled trial involving almost 5000 women at 14 centers in nine countries from 2002 through 2005.
Although uterine perforation was uncommon in both groups (<0.1%), this complication occurred three times more often among women who received misoprostol; however, the between…