One-time progesterone measurement can help predict viability if ultrasound findings are ambiguous.
When bleeding or pain occurs during early pregnancy, vaginal ultrasound commonly fails to determine viability, necessitating serial human chorionic gonadotropin assessments. Investigators conducted a meta-analysis of prospective cohort studies to determine the utility of a single serum progesterone measurement for evaluating pregnancy viability in this setting.
Five studies (1998 women; range of progesterone threshold values for viability, 3.2–6.0 ng/mL) showed that one-time progesterone measurement predicted nonviable pregnancies (i.e., miscarriage or ectopic location) with sensitivity of 75% and specificity of 98%. Median prevalence of nonviable pregnancy was 73%. If the progesterone level was below the specified threshold, the probability…
Reviewing Authors
DisclosuresRoyaltiesUpToDate
Grant/Research SupportMerck, Mithra, Medicines360
Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health
DisclosuresRoyaltiesUpToDate
Grant/Research SupportMerck, Mithra, Medicines360
Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health
DisclosuresConsultant/Advisory BoardMyovant Sciences, Inc.
Editorial BoardsEndoText; Clinical OB/GYN Alert
Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)
DisclosuresConsultant/Advisory BoardMyovant Sciences, Inc.
Editorial BoardsEndoText; Clinical OB/GYN Alert
Leadership Positions in Professional SocietiesAmerican Society for Reproductive Medicine (Member, Ethics Committee)