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For women at excess risk for ovarian cancer who have completed childbearing, risk-reducing salpingo-oophorectomy (RRSO) is an appropriate choice. However, many such women choose to defer surgery until menopause. British investigators performed annual vaginal sonograms and CA125 assessments to screen 3563 women (median age at recruitment, 45) who, based on family history or mutation carrier status, were judged to be at ≥10% lifetime risk for ovarian or fallopian tube cancer. Twenty-nine percent had undergone genetic testing; of these, about two thirds carried BRCA1 or BRCA2 mutations. At study entry, women were counseled that RRSO was recommended as the only method of preventing ovarian or fallopian tube cancer.
During a mean 3.2 years of scr…