Is Initial Salpingectomy Appropriate for BRCA Mutation Carriers?

Model suggests that primary BSO remains the best overall risk-reducing strategy for mutation carriers who have completed childbearing.

Current guidelines recommend risk-reducing bilateral salpingo-oophorectomy (BSO) for BRCA mutation carriers who have completed childbearing. BSO not only profoundly reduces mutation carriers' risk for gynecologic malignancy, but also substantially lowers future breast cancer risk. However, awareness of the downsides of surgical menopause has led many such women to defer BSO. In addition, growing recognition that many serous “ovarian” cancers in mutation carriers actually arise from the fallopian tubes have focused interest on initial salpingectomy as an alternative. Investigators used simulation modeling to compare three risk-reducing strategies for mutation carriers at age 40: BSO, salpingectomy, or salpingectomy with subsequent oophorecto…

Reviewing Author

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Andrew M. Kaunitz, MD

Disclosures

RoyaltiesUpToDate

Grant/Research SupportMerck, Mithra, Medicines360

Editorial BoardsContraception; Menopause; Contraceptive Technology Update; OBG Management; Medscape OB/GYN & Women’s Health

Is Initial Salpingectomy Appropriate for BRCA Mutation Carriers?

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Reviewing Author