Tdap Vaccination of Women During Every Pregnancy Recommended

Expanded strategy to protect neonates against pertussis

The incidence of pertussis has risen dramatically in recent years in the U.S., reflecting in part the relatively weak immunogenicity of the acellular pertussis vaccine introduced in 1996 compared with the whole-cell pertussis vaccines used before 1996. To compensate for this reduced immunogenicity, the Advisory Committee on Immunization Practices (ACIP) broadened the guidelines for tetanus toxoid, diphtheria toxoid, and acellular pertussis (Tdap) vaccination with a new recommendation to provide a booster for all adults and adolescents (JW Pediatr Adolesc Med Jul 25 2005). However, because uptake has been poor, the booster has not lowered pertussis incidence or prevented serious disease in neonates. In 2011, the ACIP recommended Tdap vaccina…

Reviewing Author

Anna Wald, MD, MPH

Disclosures

Consultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)

RoyaltiesUpToDate

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris

Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases

Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)