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Asthma is common but often misdiagnosed. Spirometry can be nondiagnostic, and bronchial provocation testing (BPT) has limitations involving accessibility, cost, and associated risks. When the diagnosis is in question, one option is to use biomarkers — specifically blood eosinophils and fractional exhaled nitric oxide (FeNO). To assess the performance of these biomarkers in the diagnosis of asthma, investigators conducted a systematic review and parallel prospective validation cohort. The systematic review included 30 studies involving ≈7100 adults with suspected asthma and normal spirometry, and the prospective cohort included ≈120 adult patients with suspected asthma who were referred to a single center. Biomarker performance was co…