Loading...
Angiotensin-converting-enzyme inhibitors and diuretics have different antihypertensive actions. Combination therapy is attractive because ACE inhibitors counterbalance the diuretic-induced activation of the renin-angiotensin system. However, conventional doses of diuretics have several adverse metabolic effects. This multicenter study tested whether low-dose combination therapy is effective and safe in patients with mild to moderate hypertension.
Researchers randomized 505 patients with diastolic pressures from 100 to 114 mm Hg to one of five 12-week regimens: lisinopril monotherapy (10 mg/day), hydrochlorothiazide monotherapy (either 12.5 or 25 mg/day), or combination therapy (lisinopril plus either of the two thiazide doses).
The two combin…