Acetaminophen After Vaccination Reduces Antibody Response

Fever is common after vaccination, leading some to recommend prophylactic antipyretics. But do such agents affect vaccine immune response? In an industry-supported study, investigators randomized healthy infants in the Czech Republic to receive vaccines alone or followed by three doses of acetaminophen (suppositories) over 24 hours. They assessed febrile response and antibody response to vaccine antigens after primary and booster doses.

The infants received 10-valent pneumococcal nontypeable Haemophilus influenzae conjugate vaccine coadministered with diphtheria–tetanus–acellular pertussis, hepatitis B, H. influenzae type B, oral rotavirus, and inactivated poliovirus types 1, 2, and 3 vaccines. Primary vaccine doses were administered at ages…