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Cluster headache is an uncommon but debilitating primary headache disorder. This review provides information about acute medical therapies for cluster headache as well as preventive medical and surgical approaches to management of cluster attacks. In discussing selected trials of various treatment options, the authors refer to level-of-evidence ratings developed by the European Federation of Neurological Societies.
Acute therapies include oxygen, sumatriptan, zolmitriptan, octreotide, lidocaine, ergotamine, and dihydroergotamine. Injectable sumatriptan and inhaled oxygen are viewed as first-line therapies for acute treatment. Preventive therapies include verapamil, lithium carbonate, topiramate, valproic acid, melatonin, baclofen, botulinum …