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Clinical guidelines recommend monitoring antiseizure medication (ASM) levels during pregnancy in patients with epilepsy, but little is known about how to successfully adjust ASM dosing in these patients to maintain seizure control and avoid adverse effects.
In a previously published cohort study, pregnant women being followed at 20 major U.S. epilepsy centers were found to have seizure rates similar to those of their nonpregnant peers and, during 18 months’ follow-up, had favorable maternal and child outcomes. Now, researchers reveal the ASM dose adjustments that were made to achieve these positive results.
Nearly all women were taking either lamotrigine or levetiracetam.
Roughly 90% of those taking lamotrigine had their dose…