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Clinicians frequently treat acute uncomplicated urinary tract infections (UTIs) empirically, but the standard 3-day course of trimethoprim-sulfamethoxazole has been compromised by the increasing prevalence of resistant organisms. Fluoroquinolones are effective, but resistance to these agents is emerging, and although nitrofurantoin is suggested as a fluoroquinolone-sparing alternative, it requires a 7-day course of treatment. To evaluate the efficacy of another possible alternative, researchers in Washington State randomized 370 symptomatic, healthy, sexually active, nonpregnant women (median age, 22; range, 18-45) to receive 3-day regimens of amoxicillin-clavulanate or the fluoroquinolone ciprofloxacin. Midstream urine and vaginal-swab spe…