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Bacterial vaginosis occurs in 15 to 20 percent of pregnant women and has been associated with obstetric complications. Metronidazole is effective therapy but is relatively contraindicated during pregnancy. This double- blind, randomized trial evaluated whether amoxicillin -- a drug considered safe in pregnancy -- is an effective alternative.
Researchers screened pregnant women for bacterial vaginosis at their first prenatal appointment and identified 108 women, between 15 and 25 weeks' gestation, with positive gram stains. All had clinical findings of vaginal discharge with an amine odor, pH greater than 4.5, or clue cells on microscopic examination. These women received either amoxicillin (500 mg three times daily) or placebo for two weeks;…