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Cardiac amyloidosis is traditionally considered to be relatively uncommon. Now, investigators have assessed its prevalence in two unique studies — the first, an evaluation of atrial biopsy results among nearly 600 patients in Japan who underwent atrial fibrillation ablation and had no prior diagnosis of amyloidosis, and the second, a retrospective review of all 2000 autopsies conducted during a 10-year period at a single Swiss hospital.
The prevalence of cardiac amyloidosis was 5% to 7% in the two studies, with amyloid transthyretin (ATTR) being the predominant type in both.
In the Japanese cohort, prevalence increased with older age, reaching 30% to 40% in subgroups with left ventricular (LV) hypertrophy, low-voltage areas …
