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Gerstmann syndrome (GS) — the tetrad of acalculia, finger agnosia, left-right disorientation, and agraphia — has been reported to be caused by lesions of the left inferior parietal lobe (LIPL). To determine the anatomical basis for GS, researchers recruited 5 healthy participants to perform writing, calculating, finger, and right-left knowledge tasks and nonspecific control tasks (e.g., hatch-mark drawing for writing) while undergoing structural and functional brain magnetic resonance imaging.
The activation patterns induced by the performance of the tasks did not overlap in a specific cortical region of the LIPL. In contrast, all the activated regions had white-matter connections that converged subcortically in the LIPL. The investigators c…