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We know that antibiotics reliably wreak havoc on the gut microbiome, but the duration of the damage has not been systematically analyzed. To study how oral antibiotics affect long-term patterns in gut flora (), Swedish researchers analyzed fecal specimens from almost 15,000 adults enrolled in three prospective health surveillance studies. About 70% of participants received at least one course of antibiotics during the study’s 8-year duration.
Even a single antibiotic course could alter the gut microbiome, with long-lasting decreases in some bacterial species and overgrowth of others. The more antibiotic courses a participant received, the more profound and persistent these changes were likely to be.
Antibiotics with …