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Infertile women undergoing in vitro fertilization (IVF) often receive anticoagulants and both active and passive immunotherapy to protect against a postulated risk for pregnancy loss or decreased chances of pregnancy due to antiphospholipid antibodies. This prospective study evaluated the relation between antiphospholipid antibodies and pregnancy rates in 793 IVF patients who were not receiving such treatment.
Researchers assayed serum samples for IgG, IgM, and IgA antibodies against cardiolipin, phosphatidyl serine, phosphatidyl ethanolamine, phosphatidyl choline, phosphatidyl inositol, phosphatidyl glycerol, and antiphosphatidic acid. Because there is currently no clear definition of "abnormal" levels of antiphospholipid antibodies (some w…